Weird Science was an American science fiction comic book magazine that was part of the EC Comics line in the early 1950s. Over a four-year span, the comic ran for 22 issues, ending with the November–December, 1953 issue. Weird Fantasy was a sister title published during the same time frame.
Due to poor sales Weird Science combined with companion comic Weird Fantasy in 1954 to become Weird Science-Fantasy. As discussed in an "In Memoriam" feature in the final issue, it was stated that every issue for the previous year and a half lost money and they had no choice but to combine the two comics into one. Weird Science-Fantasy ran for seven issues before a title change to Incredible Science Fiction for four issues.
The numbering begins with issue #12 in May 1950 (continuing from Saddle Romances #11). After issue #15 (November 1950) the numbering restarts with issue #5 in January 1951.